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Die Harran Universität forscht an einer neuen Behandlungsmethode mittels Skorpiongiftextrakten zur Bekämpfung von Brustkrebs. Dabei sollen gesunde Zelle nicht zu Schaden kommen.
One of the projects carried out in this context is Harran University Faculty of Medicine Faculty Member Assoc. Dr. It is being done by İsmail Koyuncu and his team to develop anticancer drugs for breast cancers from scorpion venom.
Stating that scorpion venoms contain many bioactive compounds that are effective against the progression of cancer, Assoc. Dr. Ismail Koyuncu; “The black scorpion (Androctanus Crassicauda) venom is the most valuable and deadly venom with exciting medical prospects and potential as a drug candidate. Several scorpion venom peptides have shown promise in many diseases. Due to its structural and functional specificity, scorpion peptides have been widely used in the development of specific drugs, especially for cancer, cardiovascular diseases and other immune system deficiencies.
Since the scorpion venom content varies according to the type of scorpion and the environment in which it lives, even the scorpion venom of the same genus has different pharmacological effects. Therefore, in this study, the metabolite profile and anti-cancer properties of black scorpion venom living in Şanlıurfa were investigated.
In this study; Venom fractions with a size in the middle of 3-10 kDa were obtained by subjecting venom collected from scorpions via electric impulse to the process. The anti-cancer effect and effect system of the obtained poison fractions on ten different cancers (breast, prostate, lung, colon, etc.) and normal cells were examined. As a result of the study, it was determined that the scorpion venom showed the strongest anti-cancer effect on breast cancer (MDA-MB-231), triggering the death mechanism we call apoptosis, and it did not harm the normal breast cells.
We are continuing our studies to investigate this effect in more detail and to determine the target molecule. With the detection of the active peptide, it will be possible to produce the drug synthetically without the need for scorpion venom.
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One of the projects carried out in this context is Harran University Faculty of Medicine Faculty Member Assoc. Dr. It is being done by İsmail Koyuncu and his team to develop anticancer drugs for breast cancers from scorpion venom.
Stating that scorpion venoms contain many bioactive compounds that are effective against the progression of cancer, Assoc. Dr. Ismail Koyuncu; “The black scorpion (Androctanus Crassicauda) venom is the most valuable and deadly venom with exciting medical prospects and potential as a drug candidate. Several scorpion venom peptides have shown promise in many diseases. Due to its structural and functional specificity, scorpion peptides have been widely used in the development of specific drugs, especially for cancer, cardiovascular diseases and other immune system deficiencies.
Since the scorpion venom content varies according to the type of scorpion and the environment in which it lives, even the scorpion venom of the same genus has different pharmacological effects. Therefore, in this study, the metabolite profile and anti-cancer properties of black scorpion venom living in Şanlıurfa were investigated.
In this study; Venom fractions with a size in the middle of 3-10 kDa were obtained by subjecting venom collected from scorpions via electric impulse to the process. The anti-cancer effect and effect system of the obtained poison fractions on ten different cancers (breast, prostate, lung, colon, etc.) and normal cells were examined. As a result of the study, it was determined that the scorpion venom showed the strongest anti-cancer effect on breast cancer (MDA-MB-231), triggering the death mechanism we call apoptosis, and it did not harm the normal breast cells.
We are continuing our studies to investigate this effect in more detail and to determine the target molecule. With the detection of the active peptide, it will be possible to produce the drug synthetically without the need for scorpion venom.
E-healthbook.com | All About Health
www.e-healthbook.com
Scorpion Venom Research Around the World: Turkish Scorpions
Pharmacological diversity of animal venoms has made them valuable sources of highly specific molecular tools in drug discovery research. Scorpion venoms contain a number of biologically active compounds, where peptides and proteins play a primary role as novel pharmacologically active molecules. In Turkey, there are 27 different species of scorpions described belonging to the Buthidae, Iuridae, Scorpionidae, and Euscorpiidae families. Despite the long history of venom research in the world, the venom of only few Turkish scorpion species has been investigated. Several health-threatening scorpions are found in Turkey, all of them belonging to the Buthidae family: Androctonus crassicauda, Buthacus macrocentrus, Leiurus abdullahbayrami, Mesobuthus eupeus, and Mesobuthus gibbosus species.
Scorpion Venom Research Around the World: Turkish Scorpions
Pharmacological diversity of animal venoms has made them valuable sources of highly specific molecular tools in drug discovery research. Scorpion venoms contain a number of biologically active compounds, where peptides and proteins play a primary role as novel...
link.springer.com
